Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 6045..6627 Replicon plasmid p15793C_57
Accession NZ_CP123368
Organism Providencia rettgeri strain PreM15793

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KOL65_RS21465 Protein ID WP_283656982.1
Coordinates 6045..6341 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KOL65_RS21470 Protein ID WP_283656983.1
Coordinates 6343..6627 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL65_RS21430 (KOL65_21715) 1338..2123 - 786 WP_283656975.1 ParB/RepB/Spo0J family partition protein -
KOL65_RS21435 (KOL65_21720) 2190..2432 - 243 WP_283656976.1 hypothetical protein -
KOL65_RS21440 (KOL65_21725) 2511..2846 - 336 WP_283656977.1 hypothetical protein -
KOL65_RS21445 (KOL65_21730) 2940..3383 - 444 WP_283656978.1 hypothetical protein -
KOL65_RS21450 (KOL65_21735) 3485..3919 - 435 WP_283656979.1 hypothetical protein -
KOL65_RS21455 (KOL65_21740) 4085..4267 - 183 WP_283656980.1 hypothetical protein -
KOL65_RS21460 (KOL65_21745) 4626..5846 - 1221 WP_283656981.1 DUF3560 domain-containing protein -
KOL65_RS21465 (KOL65_21750) 6045..6341 + 297 WP_283656982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KOL65_RS21470 (KOL65_21755) 6343..6627 + 285 WP_283656983.1 putative addiction module antidote protein Antitoxin
KOL65_RS21475 (KOL65_21760) 7073..7219 + 147 WP_283656984.1 Hok/Gef family protein -
KOL65_RS21480 (KOL65_21765) 7287..7622 - 336 WP_283656985.1 hypothetical protein -
KOL65_RS21485 (KOL65_21770) 7669..8706 - 1038 WP_283656986.1 hypothetical protein -
KOL65_RS21490 (KOL65_21775) 8731..9066 - 336 WP_283656987.1 endoribonuclease MazF -
KOL65_RS21495 (KOL65_21780) 9066..9311 - 246 WP_283656988.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
KOL65_RS21500 (KOL65_21785) 10433..11407 + 975 WP_283656989.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57581 57581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11152.05 Da        Isoelectric Point: 10.2118

>T278963 WP_283656982.1 NZ_CP123368:6045-6341 [Providencia rettgeri]
MVEIKQTDEIEKWLNSLKDKIAKAKILIRIERMAEGNMGDVQPIGHGLSELRIHQGKGYRVYFGNKNNQIILLLCGGDKT
TQQADIKKAKELAKKWGF

Download         Length: 297 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10406.85 Da        Isoelectric Point: 6.3396

>AT278963 WP_283656983.1 NZ_CP123368:6343-6627 [Providencia rettgeri]
MNKELKKFDVVEYLTTEEDIQAYLNAALEEDDNKYLFQALGNIAKARNISQLSKDTGMSREGIYKALSGEGNPSFKTVTK
ITKALGLKIQFAGA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References