Detailed information of TA system TA027896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 401952..402483
• Replicon: chromosome
• Accession: NC_018002
• Organism: Sulfurospirillum barnesii SES-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3XUX7
• Locus tag: SULBA_RS02160
• Protein ID: WP_014768631.1
• Coordinates: 402193..402483 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3XUX6
• Locus tag: SULBA_RS02155
• Protein ID: WP_014768630.1
• Coordinates: 401952..402203 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULBA_RS02130	397110..398036	+	927	WP_014768625.1	ornithine carbamoyltransferase	-
SULBA_RS02135	398036..398524	+	489	WP_014768626.1	DUF2603 domain-containing protein	-
SULBA_RS02140	398533..399906	+	1374	WP_014768627.1	oxygen-independent coproporphyrinogen III oxidase	-
SULBA_RS02145	399910..401172	+	1263	WP_014768628.1	(Fe-S)-binding protein	-
SULBA_RS02150	401224..401769	-	546	WP_014768629.1	hypothetical protein	-
SULBA_RS02155	401952..402203	+	252	WP_014768630.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SULBA_RS02160	402193..402483	+	291	WP_014768631.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SULBA_RS02165	402508..403680	-	1173	WP_014768632.1	sugar transporter	-
SULBA_RS02170	403792..404187	+	396	WP_014768633.1	SEC-C domain-containing protein	-
SULBA_RS02175	404184..404843	+	660	WP_172634065.1	cyclic nucleotide-binding domain-containing protein	-
SULBA_RS02180	404920..405351	+	432	WP_014768635.1	Hsp20/alpha crystallin family protein	-
SULBA_RS02185	405474..406292	+	819	WP_014768636.1	prolipoprotein diacylglyceryl transferase	-
SULBA_RS02190	406485..407267	+	783	WP_041671758.1	fumarate reductase cytochrome b subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11487.49 Da
• Isoelectric Point: 10.1568

>T27896 WP_014768631.1 NC_018002:402193-402483 [Sulfurospirillum barnesii SES-3]
MRYELEFHPQALKEWKNLGETIKEQFKKKLQERLENPKVPKDKLVGFDAVYKIKLKTAGYRLAYEVIDERVVIIVLVIGK
RENNKVYNALYSRFEK

Nucleotide

• Length: 291 bp

>T27896 NC_018002:402193-402483 [Sulfurospirillum barnesii SES-3]
ATGCGCTATGAATTAGAATTTCACCCACAAGCGCTAAAAGAGTGGAAAAATCTAGGTGAAACCATCAAAGAGCAGTTTAA
AAAGAAACTGCAAGAGAGACTGGAAAACCCAAAAGTTCCTAAAGACAAACTCGTTGGATTTGATGCAGTCTACAAAATCA
AACTCAAAACAGCAGGATACAGATTAGCCTATGAAGTGATTGATGAAAGAGTGGTTATTATCGTTTTAGTGATAGGAAAA
CGTGAAAACAATAAAGTGTATAATGCTCTGTATTCACGTTTTGAGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9261.73 Da
• Isoelectric Point: 4.6653

>AT27896 WP_014768630.1 NC_018002:401952-402203 [Sulfurospirillum barnesii SES-3]
MQPILSNYTASITELKKSPTQILENAGEEVVAILNHNVVSAYLVPSKTYEKLMAMLDDYMLSKEVISRQSEAYTPIKVTL
DAL

Nucleotide

• Length: 252 bp

>AT27896 NC_018002:401952-402203 [Sulfurospirillum barnesii SES-3]
ATGCAACCTATTTTATCAAACTACACAGCAAGCATTACTGAGCTTAAAAAATCACCCACGCAAATTCTTGAAAATGCAGG
CGAAGAAGTTGTTGCTATACTCAATCATAATGTGGTAAGTGCTTACCTTGTTCCTTCTAAAACCTATGAAAAATTGATGG
CGATGCTGGATGATTATATGCTCTCTAAAGAAGTTATAAGTAGACAAAGCGAAGCTTACACACCTATTAAAGTAACGCTT
GATGCGCTATGA

Structures

Toxin

• AlphaFold DB: I3XUX7

Antitoxin

• AlphaFold DB: I3XUX6