Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3589632..3590263 Replicon chromosome
Accession NZ_CP123365
Organism Shigella flexneri strain MMGSG_23

Toxin (Protein)


Gene name hicA Uniprot ID A0A822PMR8
Locus tag PFB08_RS18330 Protein ID WP_001259384.1
Coordinates 3589988..3590263 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PFB08_RS18325 Protein ID WP_000593555.1
Coordinates 3589632..3589991 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFB08_RS18300 (3585764) 3585764..3586708 + 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -
PFB08_RS18305 (3586705) 3586705..3587538 + 834 WP_001008973.1 nickel ABC transporter permease subunit NikC -
PFB08_RS18310 (3587538) 3587538..3588302 + 765 WP_001136253.1 nickel import ATP-binding protein NikD -
PFB08_RS18315 (3588299) 3588299..3589105 + 807 WP_000173660.1 nickel import ATP-binding protein NikE -
PFB08_RS18320 (3589111) 3589111..3589512 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PFB08_RS18325 (3589632) 3589632..3589991 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PFB08_RS18330 (3589988) 3589988..3590263 - 276 WP_001259384.1 type II toxin-antitoxin system HicA family toxin Toxin
PFB08_RS18335 (3590322) 3590322..3591446 - 1125 WP_001216257.1 ABC transporter permease -
PFB08_RS18340 (3591446) 3591446..3594181 - 2736 WP_000149173.1 ribosome-associated ATPase/putative transporter RbbA -
PFB08_RS18345 (3594178) 3594178..3595245 - 1068 WP_000361470.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10146.89 Da        Isoelectric Point: 10.3748

>T278959 WP_001259384.1 NZ_CP123365:c3590263-3589988 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT278959 WP_000593555.1 NZ_CP123365:c3589991-3589632 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822PMR8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References