Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2974330..2974984 Replicon chromosome
Accession NZ_CP123365
Organism Shigella flexneri strain MMGSG_23

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag PFB08_RS15175 Protein ID WP_000244767.1
Coordinates 2974330..2974737 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag PFB08_RS15180 Protein ID WP_000354044.1
Coordinates 2974718..2974984 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFB08_RS15155 (2970287) 2970287..2972020 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
PFB08_RS15160 (2972026) 2972026..2972736 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PFB08_RS15165 (2972761) 2972761..2973657 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
PFB08_RS15170 (2973769) 2973769..2974290 + 522 WP_001055867.1 flavodoxin FldB -
PFB08_RS15175 (2974330) 2974330..2974737 - 408 WP_000244767.1 protein YgfX Toxin
PFB08_RS15180 (2974718) 2974718..2974984 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
PFB08_RS15185 (2975227) 2975227..2976207 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PFB08_RS15190 (2976403) 2976403..2977062 - 660 WP_000250274.1 hemolysin III family protein -
PFB08_RS15195 (2977226) 2977226..2977536 - 311 Protein_2961 N(4)-acetylcytidine aminohydrolase -
PFB08_RS15200 (2977581) 2977581..2979014 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
PFB08_RS15205 (2979071) 2979071..2979814 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T278956 WP_000244767.1 NZ_CP123365:c2974737-2974330 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT278956 WP_000354044.1 NZ_CP123365:c2974984-2974718 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References