Detailed information of TA system TA278934

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 768527..769994
• Replicon: chromosome
• Accession: NZ_CP123308
• Organism: Mycoplasmopsis bovis strain 16DD0100

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q932V7
• Locus tag: QEP30_RS03310
• Protein ID: WP_041309184.1
• Coordinates: 769134..769994 (+)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: QEP30_RS03305
• Protein ID: WP_013456322.1
• Coordinates: 768527..769141 (+)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QEP30_RS03285	763894..764922	+	1029	WP_078086175.1	IS30-like element ISMbov1 family transposase	-
QEP30_RS03290	765304..766029	-	726	WP_013456472.1	variable surface lipoprotein	-
QEP30_RS03295	766178..767269	-	1092	WP_280124971.1	variable surface lipoprotein	-
QEP30_RS03300	767454..768344	-	891	WP_075271150.1	variable surface lipoprotein	-
QEP30_RS03305	768527..769141	+	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QEP30_RS03310	769134..769994	+	861	WP_041309184.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QEP30_RS03315	770114..770689	+	576	WP_075271397.1	variable surface lipoprotein	-
QEP30_RS03320	770732..771457	-	726	WP_075271933.1	variable surface lipoprotein	-
QEP30_RS03325	771632..772186	-	555	WP_280124972.1	variable surface lipoprotein	-
QEP30_RS03330	772611..773638	-	1028	Protein_629	IS30-like element ISMbov1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	763804..764922	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33281.35 Da
• Isoelectric Point: 7.2878

>T278934 WP_041309184.1 NZ_CP123308:769134-769994 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT278934 WP_013456322.1 NZ_CP123308:768527-769141 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

Structures

Toxin

• AlphaFold DB: Q932V7

Antitoxin

• AlphaFold DB: Q934C3