Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 814145..815612 Replicon chromosome
Accession NZ_CP123302
Organism Mycoplasmopsis bovis strain 15DD0249

Toxin (Protein)


Gene name abiEi Uniprot ID A0A2N8U3K6
Locus tag QEP32_RS03510 Protein ID WP_014829995.1
Coordinates 814752..815612 (+) Length 287 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q934C3
Locus tag QEP32_RS03505 Protein ID WP_013456322.1
Coordinates 814145..814759 (+) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP32_RS03480 809826..810855 - 1030 Protein_660 IS30-like element ISMbov1 family transposase -
QEP32_RS03490 811479..812228 - 750 WP_013456123.1 tyrosine-type recombinase/integrase -
QEP32_RS03495 812514..813089 + 576 WP_280124673.1 variable surface lipoprotein -
QEP32_RS03500 813132..813962 - 831 Protein_663 variable surface lipoprotein -
QEP32_RS03505 814145..814759 + 615 WP_013456322.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QEP32_RS03510 814752..815612 + 861 WP_014829995.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QEP32_RS03515 815733..816458 + 726 WP_280124674.1 variable surface lipoprotein -
QEP32_RS03520 816634..817530 + 897 WP_280124675.1 variable surface lipoprotein -
QEP32_RS03525 817689..818321 + 633 WP_280124676.1 variable surface lipoprotein -
QEP32_RS03530 818580..819188 - 609 WP_115276525.1 variable surface lipoprotein -
QEP32_RS03535 819364..819966 - 603 WP_280124677.1 variable surface lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-234)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(13-59)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 33280.36 Da        Isoelectric Point: 7.7731

>T278929 WP_014829995.1 NZ_CP123302:814752-815612 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Download         Length: 861 bp

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 24143.83 Da        Isoelectric Point: 9.7617

>AT278929 WP_013456322.1 NZ_CP123302:814145-814759 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Download         Length: 615 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8U3K6

Antitoxin

Source ID Structure
AlphaFold DB Q934C3

References