Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 756008..757475 | Replicon | chromosome |
| Accession | NZ_CP123300 | ||
| Organism | Mycoplasmopsis bovis strain 15DD0238 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | A0A2N8U3K6 |
| Locus tag | QEP61_RS03330 | Protein ID | WP_014829995.1 |
| Coordinates | 756615..757475 (+) | Length | 287 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | Q934C3 |
| Locus tag | QEP61_RS03325 | Protein ID | WP_013456322.1 |
| Coordinates | 756008..756622 (+) | Length | 205 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QEP61_RS03310 | 752058..753302 | - | 1245 | WP_013954995.1 | IS3 family transposase | - |
| QEP61_RS03315 | 753638..755071 | + | 1434 | WP_013455919.1 | transposase | - |
| QEP61_RS03320 | 755090..755743 | - | 654 | WP_214469033.1 | hypothetical protein | - |
| QEP61_RS03325 | 756008..756622 | + | 615 | WP_013456322.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| QEP61_RS03330 | 756615..757475 | + | 861 | WP_014829995.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| QEP61_RS03335 | 757593..758303 | + | 711 | WP_280125053.1 | variable surface lipoprotein | - |
| QEP61_RS03340 | 758479..759222 | + | 744 | WP_280125018.1 | variable surface lipoprotein | - |
| QEP61_RS03345 | 759362..760453 | - | 1092 | WP_099620147.1 | variable surface lipoprotein | - |
| QEP61_RS03350 | 760598..761338 | - | 741 | WP_280125019.1 | variable surface lipoprotein | - |
| QEP61_RS03355 | 761515..762231 | - | 717 | WP_280125020.1 | variable surface lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 752136..775463 | 23327 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 287 a.a. Molecular weight: 33280.36 Da Isoelectric Point: 7.7731
>T278927 WP_014829995.1 NZ_CP123300:756615-757475 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
Download Length: 861 bp
Antitoxin
Download Length: 205 a.a. Molecular weight: 24143.83 Da Isoelectric Point: 9.7617
>AT278927 WP_013456322.1 NZ_CP123300:756008-756622 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
Download Length: 615 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N8U3K6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q934C3 |