Detailed information of TA system TA278924

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 939312..940779
• Replicon: chromosome
• Accession: NZ_CP123297
• Organism: Mycoplasmopsis bovis strain 15DD0228

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q932V7
• Locus tag: QEP58_RS04080
• Protein ID: WP_041309184.1
• Coordinates: 939312..940172 (-)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: QEP58_RS04085
• Protein ID: WP_013456322.1
• Coordinates: 940165..940779 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QEP58_RS04050	935170..936198	-	1029	WP_280133236.1	IS30-like element ISMbov1 family transposase	-
QEP58_RS04055	936576..936758	+	183	WP_235125612.1	helix-turn-helix domain-containing protein	-
QEP58_RS04060	936863..937501	+	639	WP_235125609.1	IS30 family transposase	-
QEP58_RS04065	937893..938117	-	225	WP_041309186.1	hypothetical protein	-
QEP58_RS04070	938155..938364	+	210	WP_041309187.1	hypothetical protein	-
QEP58_RS04075	938446..939192	-	747	WP_280124637.1	variable surface lipoprotein	-
QEP58_RS04080	939312..940172	-	861	WP_041309184.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QEP58_RS04085	940165..940779	-	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QEP58_RS04090	940963..941100	+	138	Protein_775	variable surface lipoprotein	-
QEP58_RS04095	941379..942269	+	891	WP_075271150.1	variable surface lipoprotein	-
QEP58_RS04100	942458..942562	+	105	Protein_777	variable surface lipoprotein	-
QEP58_RS04105	942984..943220	-	237	WP_280124644.1	hypothetical protein	-
QEP58_RS04110	943388..944113	+	726	WP_075271933.1	variable surface lipoprotein	-
QEP58_RS04115	944156..944731	-	576	WP_075271397.1	variable surface lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	905175..967278	62103
	-	flank	IS/Tn	-	-	935170..936288	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33281.35 Da
• Isoelectric Point: 7.2878

>T278924 WP_041309184.1 NZ_CP123297:c940172-939312 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT278924 WP_013456322.1 NZ_CP123297:c940779-940165 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

Structures

Toxin

• AlphaFold DB: Q932V7

Antitoxin

• AlphaFold DB: Q934C3