Detailed information of TA system TA027892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3926680..3928149
• Replicon: chromosome
• Accession: NC_017964
• Organism: Advenella kashmirensis WT001

Toxin (Protein)

• Gene name: panT
• Uniprot ID: I3UGQ6
• Locus tag: TKWG_RS18435
• Protein ID: WP_014752285.1
• Coordinates: 3926680..3927672 (-)
• Length: 331 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: I3UGQ7
• Locus tag: TKWG_RS18440
• Protein ID: WP_014752286.1
• Coordinates: 3927682..3928149 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TKWG_RS18405	3921761..3922555	+	795	WP_014752281.1	EI24 domain-containing protein	-
TKWG_RS18410	3922569..3922898	-	330	WP_014752282.1	Grx4 family monothiol glutaredoxin	-
TKWG_RS18415	3922969..3923796	-	828	WP_014752283.1	peptide chain release factor N(5)-glutamine methyltransferase	-
TKWG_RS18420	3923869..3924954	-	1086	WP_014752284.1	peptide chain release factor 1	-
TKWG_RS18425	3925041..3926316	-	1276	Protein_3745	glutamyl-tRNA reductase	-
TKWG_RS18435	3926680..3927672	-	993	WP_014752285.1	hypothetical protein	Toxin
TKWG_RS18440	3927682..3928149	-	468	WP_014752286.1	DUF4065 domain-containing protein	Antitoxin
TKWG_RS18445	3928371..3928658	-	288	WP_014752287.1	hypothetical protein	-
TKWG_RS18450	3928720..3930924	-	2205	WP_014752288.1	DEAD/DEAH box helicase	-
TKWG_RS18455	3930944..3932247	-	1304	Protein_3750	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (28-127)

Sequences

Toxin

Protein

• Length: 331 a.a.
• Molecular weight: 37495.97 Da
• Isoelectric Point: 8.7206

>T27892 WP_014752285.1 NC_017964:c3927672-3926680 [Advenella kashmirensis WT001]
MAVKKKSKKQDAESAAQDTLLDNIKIKRSAVPNDKKDEVDYSIDAIAPKFVKYEERIVAFVDILGFKEIVLRSQKDPDLV
NQIYNGLDVRKDELARHFVAELGLSLSPEDFDDRFHTFSDCIVMSVDSKIEELGLLIFMIFKICRQLLLAGFLSRGGVAI
GQLLHLTPESTPGSDRNSSMVFGPAFVDAYNLESSHAGCARIILQQKLRQMIHDHRQKHPYKKLTKFFDAHVSRADDGPA
FVNQFADFPGNNFYEENVDVQPDIKAIQAHLQEKLNEVSDKPYHFQKNAILAREFNNAIKLASKVPRYADCKKYIISSDA
LPGKRRKPRR

Nucleotide

• Length: 993 bp

>T27892 NC_017964:c3927672-3926680 [Advenella kashmirensis WT001]
ATGGCTGTTAAGAAGAAAAGTAAAAAGCAGGATGCTGAATCGGCCGCACAAGACACACTCTTAGACAATATTAAGATTAA
GCGTAGCGCTGTTCCTAATGATAAAAAGGACGAGGTAGATTATTCAATTGACGCTATTGCTCCAAAATTTGTTAAATATG
AAGAGCGAATAGTCGCGTTTGTCGATATTTTGGGGTTCAAGGAGATCGTTTTGCGGTCACAAAAGGACCCTGATCTGGTG
AATCAGATATATAACGGGCTAGATGTTAGAAAGGATGAATTAGCGCGACACTTTGTGGCGGAGTTAGGGCTATCGCTTTC
CCCGGAAGATTTCGACGATCGATTCCATACATTTTCTGATTGTATTGTGATGTCAGTAGATTCCAAAATAGAAGAGTTAG
GCCTTCTCATTTTTATGATTTTCAAAATCTGCAGGCAATTATTATTGGCTGGATTTTTAAGTAGAGGAGGAGTGGCAATA
GGACAACTTTTACACTTAACTCCTGAATCCACACCCGGATCTGACCGGAACTCGTCGATGGTATTTGGCCCCGCTTTTGT
TGATGCATATAATCTTGAGTCAAGTCATGCTGGCTGTGCGAGAATTATTCTGCAGCAAAAGTTAAGACAAATGATTCATG
ATCATAGACAAAAGCATCCATATAAAAAACTAACAAAATTTTTTGATGCCCATGTGTCGCGTGCTGATGATGGCCCCGCA
TTTGTGAATCAATTTGCCGATTTTCCTGGTAATAATTTTTATGAGGAAAATGTTGATGTCCAGCCCGACATCAAAGCGAT
ACAGGCGCATCTTCAAGAAAAGCTTAACGAAGTGTCAGATAAACCCTATCATTTTCAGAAGAATGCGATCTTAGCGCGAG
AGTTTAATAATGCAATTAAATTAGCATCTAAAGTACCAAGATATGCAGACTGCAAAAAATATATTATTTCATCAGATGCG
CTTCCTGGTAAAAGACGCAAACCAAGGAGGTAG

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17664.98 Da
• Isoelectric Point: 5.2540

>AT27892 WP_014752286.1 NC_017964:c3928149-3927682 [Advenella kashmirensis WT001]
MSITALQLGSELVRRAAKRNFKLTNLSLQKLAYFAHGWHLALFDKPLLEENDAFEAWRYGPVLPELYHALKAFSNNNIPA
DHPLIASQEELDSTRVEAKLIEKILDEYGNFSSFQLVRLSHDPDGPWAKVYSEPGFSIAIDDDSIGRFFKKDLEN

Nucleotide

• Length: 468 bp

>AT27892 NC_017964:c3928149-3927682 [Advenella kashmirensis WT001]
ATGTCTATCACTGCATTACAACTTGGTAGTGAGTTGGTTCGTCGTGCGGCCAAAAGGAATTTCAAATTAACCAATTTATC
ATTACAAAAATTGGCATATTTTGCCCATGGCTGGCATTTAGCATTATTTGATAAACCATTGTTAGAGGAAAACGATGCGT
TTGAGGCATGGCGTTATGGCCCTGTTTTACCAGAGCTATATCATGCGTTGAAAGCGTTTTCCAATAATAATATTCCTGCG
GATCACCCATTGATTGCTTCGCAAGAAGAATTGGACTCTACTCGGGTTGAAGCTAAGCTAATTGAAAAAATTCTGGATGA
ATATGGAAATTTTTCCAGTTTTCAGCTTGTGCGATTATCCCACGATCCTGACGGTCCATGGGCGAAAGTATATTCTGAGC
CAGGTTTTTCCATCGCTATTGACGATGATAGTATCGGACGCTTTTTCAAAAAAGATTTAGAAAATTAA

Structures

Toxin

• AlphaFold DB: I3UGQ6

Antitoxin

• AlphaFold DB: I3UGQ7