Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 279065..280532 Replicon chromosome
Accession NZ_CP123288
Organism Mycoplasmopsis bovis strain 15DD0141

Toxin (Protein)


Gene name abiEi Uniprot ID A0A2N8U3K6
Locus tag QEP35_RS01300 Protein ID WP_014829995.1
Coordinates 279065..279925 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q934C3
Locus tag QEP35_RS01305 Protein ID WP_013456322.1
Coordinates 279918..280532 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP35_RS01275 274496..274699 - 204 WP_280135600.1 variable surface lipoprotein -
QEP35_RS01280 275403..275624 + 222 WP_280135601.1 variable surface lipoprotein -
QEP35_RS01285 275621..276289 - 669 WP_280135602.1 hypothetical protein -
QEP35_RS01290 276320..277753 - 1434 WP_101456648.1 transposase -
QEP35_RS01295 278286..278945 - 660 WP_280135611.1 variable surface lipoprotein -
QEP35_RS01300 279065..279925 - 861 WP_014829995.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QEP35_RS01305 279918..280532 - 615 WP_013456322.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QEP35_RS01310 280715..281299 + 585 WP_280135603.1 variable surface lipoprotein -
QEP35_RS01315 281694..282011 + 318 WP_280135619.1 hypothetical protein -
QEP35_RS01320 282016..282123 - 108 Protein_243 variable surface lipoprotein -
QEP35_RS01325 282409..283158 + 750 WP_013456123.1 tyrosine-type recombinase/integrase -
QEP35_RS01335 283782..284810 + 1029 WP_280135612.1 IS30-like element ISMbov1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 283692..284810 1118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-234)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(13-59)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 33280.36 Da        Isoelectric Point: 7.7731

>T278917 WP_014829995.1 NZ_CP123288:c279925-279065 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Download         Length: 861 bp

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 24143.83 Da        Isoelectric Point: 9.7617

>AT278917 WP_013456322.1 NZ_CP123288:c280532-279918 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Download         Length: 615 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8U3K6

Antitoxin

Source ID Structure
AlphaFold DB Q934C3

References