Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 292815..294282 Replicon chromosome
Accession NZ_CP123287
Organism Mycoplasmopsis bovis strain 14DD0475

Toxin (Protein)


Gene name abiEi Uniprot ID A0A2N8U3K6
Locus tag QEP49_RS01285 Protein ID WP_014829995.1
Coordinates 292815..293675 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q934C3
Locus tag QEP49_RS01290 Protein ID WP_013456322.1
Coordinates 293668..294282 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP49_RS01260 288320..289045 - 726 WP_280133200.1 variable surface lipoprotein -
QEP49_RS01265 289748..290839 + 1092 WP_099620147.1 variable surface lipoprotein -
QEP49_RS01270 290882..291712 - 831 Protein_240 variable surface lipoprotein -
QEP49_RS01275 291862..292065 + 204 WP_214461281.1 hypothetical protein -
QEP49_RS01280 292062..292652 - 591 WP_280133201.1 variable surface lipoprotein -
QEP49_RS01285 292815..293675 - 861 WP_014829995.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QEP49_RS01290 293668..294282 - 615 WP_013456322.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QEP49_RS01295 294465..295820 + 1356 WP_280133202.1 variable surface lipoprotein -
QEP49_RS01300 296005..296613 + 609 WP_115276525.1 variable surface lipoprotein -
QEP49_RS01305 296872..297480 - 609 WP_280133203.1 variable surface lipoprotein -
QEP49_RS01310 298026..299033 - 1008 WP_013955061.1 ECF transporter S component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 278459..328289 49830
- flank IS/Tn - - 299244..300362 1118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-234)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(13-59)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 33280.36 Da        Isoelectric Point: 7.7731

>T278916 WP_014829995.1 NZ_CP123287:c293675-292815 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Download         Length: 861 bp

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 24143.83 Da        Isoelectric Point: 9.7617

>AT278916 WP_013456322.1 NZ_CP123287:c294282-293668 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Download         Length: 615 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8U3K6

Antitoxin

Source ID Structure
AlphaFold DB Q934C3

References