Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 304262..305729 | Replicon | chromosome |
| Accession | NZ_CP123286 | ||
| Organism | Mycoplasmopsis bovis strain 14DD0147 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | A0A2N8U3K6 |
| Locus tag | QEP51_RS01330 | Protein ID | WP_014829995.1 |
| Coordinates | 304869..305729 (+) | Length | 287 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | Q934C3 |
| Locus tag | QEP51_RS01325 | Protein ID | WP_013456322.1 |
| Coordinates | 304262..304876 (+) | Length | 205 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QEP51_RS01305 | 300157..300822 | + | 666 | WP_280131215.1 | variable surface lipoprotein | - |
| QEP51_RS01310 | 300825..302258 | - | 1434 | WP_101456648.1 | transposase | - |
| QEP51_RS01315 | 302788..303303 | - | 516 | WP_280131216.1 | variable surface lipoprotein | - |
| QEP51_RS01320 | 303479..304078 | - | 600 | WP_280131217.1 | variable surface lipoprotein | - |
| QEP51_RS01325 | 304262..304876 | + | 615 | WP_013456322.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| QEP51_RS01330 | 304869..305729 | + | 861 | WP_014829995.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| QEP51_RS01335 | 305849..306505 | + | 657 | WP_226060959.1 | variable surface lipoprotein | - |
| QEP51_RS01340 | 306764..307333 | - | 570 | WP_280131218.1 | variable surface lipoprotein | - |
| QEP51_RS01345 | 307879..308886 | - | 1008 | WP_280131219.1 | ECF transporter S component | - |
| QEP51_RS01350 | 309097..310125 | - | 1029 | WP_078086180.1 | IS30-like element ISMbov1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 283748..336108 | 52360 | |
| - | flank | IS/Tn | - | - | 309097..310215 | 1118 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 287 a.a. Molecular weight: 33280.36 Da Isoelectric Point: 7.7731
>T278915 WP_014829995.1 NZ_CP123286:304869-305729 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND
Download Length: 861 bp
Antitoxin
Download Length: 205 a.a. Molecular weight: 24143.83 Da Isoelectric Point: 9.7617
>AT278915 WP_013456322.1 NZ_CP123286:304262-304876 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE
Download Length: 615 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N8U3K6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q934C3 |