Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 23334..23856 Replicon plasmid unnamed
Accession NZ_CP123283
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag QEN32_RS22610 Protein ID WP_000220560.1
Coordinates 23334..23615 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QEN32_RS22615 Protein ID WP_000121743.1
Coordinates 23605..23856 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS22580 18351..18701 + 351 WP_000454193.1 DUF3330 domain-containing protein -
QEN32_RS22585 18877..19092 + 216 Protein_24 recombinase family protein -
QEN32_RS22590 19157..19861 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
QEN32_RS22595 19913..20656 - 744 Protein_26 IS5 family transposase -
QEN32_RS22600 22244..22552 - 309 Protein_27 replication initiation protein -
QEN32_RS22610 23334..23615 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEN32_RS22615 23605..23856 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QEN32_RS22620 25090..25926 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
QEN32_RS22625 25966..26412 + 447 Protein_32 hypothetical protein -
QEN32_RS22630 26549..26905 + 357 WP_000456533.1 DNA distortion polypeptide 3 -
QEN32_RS22635 26902..27879 - 978 WP_024245156.1 hypothetical protein -
QEN32_RS22640 27904..28185 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / blaTEM-1B / sul3 / qnrS1 / aadA2 - 1..29276 29276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T278914 WP_000220560.1 NZ_CP123283:c23615-23334 [Salmonella sp. SA14318]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT278914 WP_000121743.1 NZ_CP123283:c23856-23605 [Salmonella sp. SA14318]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References