Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4205977..4206758 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag QEN32_RS20100 Protein ID WP_079945808.1
Coordinates 4205977..4206468 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag QEN32_RS20105 Protein ID WP_001110453.1
Coordinates 4206465..4206758 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS20070 (4201642) 4201642..4202391 - 750 WP_001747728.1 PTS sugar transporter subunit IIC -
QEN32_RS20075 (4202444) 4202444..4202926 - 483 WP_000108907.1 PTS sugar transporter subunit IIB -
QEN32_RS20080 (4202944) 4202944..4203333 - 390 WP_001639590.1 mannose/fructose/sorbose PTS transporter subunit IIA -
QEN32_RS20085 (4203601) 4203601..4204413 + 813 Protein_3924 IS3 family transposase -
QEN32_RS20090 (4204816) 4204816..4204892 + 77 Protein_3925 porin family protein -
QEN32_RS20095 (4204992) 4204992..4205744 + 753 WP_023181278.1 non-specific acid phosphatase -
QEN32_RS20100 (4205977) 4205977..4206468 - 492 WP_079945808.1 GNAT family N-acetyltransferase Toxin
QEN32_RS20105 (4206465) 4206465..4206758 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
QEN32_RS20110 (4207076) 4207076..4207297 + 222 WP_265322051.1 hypothetical protein -
QEN32_RS20115 (4207561) 4207561..4208436 + 876 WP_000921674.1 AraC family transcriptional regulator -
QEN32_RS20120 (4208433) 4208433..4208720 + 288 WP_001269916.1 transcriptional regulator RtsB -
QEN32_RS20125 (4208713) 4208713..4208994 - 282 WP_265322079.1 ATP-binding cassette domain-containing protein -
QEN32_RS20130 (4208915) 4208915..4209117 + 203 Protein_3933 hypothetical protein -
QEN32_RS20135 (4209125) 4209125..4209424 + 300 WP_265322080.1 Ig-like domain-containing protein -
QEN32_RS20140 (4209804) 4209804..4210709 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4194579..4209424 14845
- flank IS/Tn - - 4204084..4204413 329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17635.43 Da        Isoelectric Point: 7.7297

>T278911 WP_079945808.1 NZ_CP123282:c4206468-4205977 [Salmonella sp. SA14318]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT278911 WP_001110453.1 NZ_CP123282:c4206758-4206465 [Salmonella sp. SA14318]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References