278910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4068408..4069051 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag QEN32_RS19400 Protein ID WP_000048134.1
Coordinates 4068635..4069051 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag QEN32_RS19395 Protein ID WP_001261294.1
Coordinates 4068408..4068638 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS19380 (4063457) 4063457..4065109 + 1653 WP_114051902.1 alpha,alpha-phosphotrehalase -
QEN32_RS19385 (4065518) 4065518..4067656 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
QEN32_RS19390 (4067777) 4067777..4068241 + 465 WP_265322038.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QEN32_RS19395 (4068408) 4068408..4068638 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QEN32_RS19400 (4068635) 4068635..4069051 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN32_RS19405 (4069112) 4069112..4071025 - 1914 WP_265322039.1 BglG family transcription antiterminator -
QEN32_RS19410 (4071042) 4071042..4071782 - 741 WP_064047084.1 KDGP aldolase family protein -
QEN32_RS19415 (4071779) 4071779..4072897 - 1119 WP_183055924.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QEN32_RS19420 (4072881) 4072881..4074014 - 1134 WP_265322040.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T278910 WP_000048134.1 NZ_CP123282:4068635-4069051 [Salmonella sp. SA14318]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT278910 WP_001261294.1 NZ_CP123282:4068408-4068638 [Salmonella sp. SA14318]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References