Detailed information of TA system TA027891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3644599..3645121
• Replicon: chromosome
• Accession: NC_017964
• Organism: Advenella kashmirensis WT001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TKWG_RS17075
• Protein ID: WP_014752033.1
• Coordinates: 3644599..3644787 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3UG05
• Locus tag: TKWG_RS17080
• Protein ID: WP_014752034.1
• Coordinates: 3644849..3645121 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TKWG_RS17055	3640201..3641150	-	950	Protein_3455	tripartite tricarboxylate transporter substrate binding protein	-
TKWG_RS22785	3641282..3641980	-	699	WP_081489330.1	carbon-nitrogen hydrolase family protein	-
TKWG_RS17065	3642254..3643597	+	1344	WP_014752031.1	aspartate aminotransferase family protein	-
TKWG_RS17070	3643631..3644497	+	867	WP_014752032.1	MurR/RpiR family transcriptional regulator	-
TKWG_RS17075	3644599..3644787	-	189	WP_014752033.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TKWG_RS17080	3644849..3645121	-	273	WP_014752034.1	ribbon-helix-helix protein, CopG family	Antitoxin
TKWG_RS17085	3645288..3645854	-	567	WP_014752035.1	ABATE domain-containing protein	-
TKWG_RS24135	3645958..3646119	+	162	WP_202947730.1	hypothetical protein	-
TKWG_RS17090	3646110..3647126	+	1017	WP_202947731.1	epoxide hydrolase	-
TKWG_RS17095	3647149..3647961	-	813	WP_014752036.1	hypothetical protein	-
TKWG_RS22790	3648288..3648536	-	249	WP_014752037.1	hypothetical protein	-
TKWG_RS17100	3648540..3649460	-	921	WP_014752038.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3577311..3805311	228000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-61)

Antitoxin

• Ribbon-helix-helix protein, CopG (17-46)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7145.24 Da
• Isoelectric Point: 10.0912

>T27891 WP_014752033.1 NC_017964:c3644787-3644599 [Advenella kashmirensis WT001]
VNKSAAARAVQKLTKAPTILLTDSRIGEQLFQFEPRDVRRILAGHYETRYEIQGETIYVLRL

Nucleotide

• Length: 189 bp

>T27891 NC_017964:c3644787-3644599 [Advenella kashmirensis WT001]
GTGAACAAATCAGCCGCTGCCAGAGCGGTGCAAAAGCTAACCAAAGCCCCAACCATATTGTTAACCGATTCGCGCATTGG
CGAACAATTGTTCCAGTTCGAGCCGCGTGACGTGCGCCGCATTCTGGCAGGACATTATGAAACTCGCTACGAAATTCAGG
GTGAAACGATCTATGTGCTGCGGCTGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10138.50 Da
• Isoelectric Point: 4.8430

>AT27891 WP_014752034.1 NC_017964:c3645121-3644849 [Advenella kashmirensis WT001]
MPKAETRVLTALVPVLLAEKVDQLADRLRRSRGWIIKQALSAWIAQEEERDRLTQEALAEVEGGHFVDHQAVQAWADSLS
DQEPLPVPRS

Nucleotide

• Length: 273 bp

>AT27891 NC_017964:c3645121-3644849 [Advenella kashmirensis WT001]
ATGCCTAAAGCCGAAACACGCGTGCTTACCGCGCTCGTCCCCGTATTACTTGCAGAGAAAGTGGACCAATTGGCAGATCG
GCTTAGGCGTTCTCGTGGCTGGATTATAAAACAAGCACTTTCAGCCTGGATCGCCCAGGAGGAAGAGCGCGACCGCCTGA
CACAGGAGGCGCTGGCTGAAGTGGAGGGTGGTCATTTTGTTGATCATCAAGCCGTGCAAGCTTGGGCTGACAGTCTGAGC
GACCAGGAACCACTGCCGGTACCTCGCTCATGA

Structures

Antitoxin

• AlphaFold DB: I3UG05