Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3359886..3360506 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QEN32_RS16160 Protein ID WP_001280991.1
Coordinates 3360288..3360506 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QEN32_RS16155 Protein ID WP_000344807.1
Coordinates 3359886..3360260 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS16145 (3355025) 3355025..3356218 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN32_RS16150 (3356241) 3356241..3359390 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QEN32_RS16155 (3359886) 3359886..3360260 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QEN32_RS16160 (3360288) 3360288..3360506 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QEN32_RS16165 (3360685) 3360685..3361236 + 552 WP_001278793.1 maltose O-acetyltransferase -
QEN32_RS16170 (3361354) 3361354..3361824 + 471 WP_000136183.1 YlaC family protein -
QEN32_RS16175 (3361880) 3361880..3362020 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QEN32_RS16180 (3362026) 3362026..3362286 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QEN32_RS16185 (3362511) 3362511..3364061 + 1551 WP_000213145.1 EAL domain-containing protein -
QEN32_RS16195 (3364292) 3364292..3364681 + 390 WP_000961286.1 MGMT family protein -
QEN32_RS16200 (3364714) 3364714..3365283 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T278906 WP_001280991.1 NZ_CP123282:3360288-3360506 [Salmonella sp. SA14318]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT278906 WP_000344807.1 NZ_CP123282:3359886-3360260 [Salmonella sp. SA14318]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References