Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2361259..2361781 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag QEN32_RS11265 Protein ID WP_000221345.1
Coordinates 2361497..2361781 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag QEN32_RS11260 Protein ID WP_000885424.1
Coordinates 2361259..2361507 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS11235 (2357317) 2357317..2358225 - 909 WP_265322119.1 LysR family transcriptional regulator -
QEN32_RS11240 (2358627) 2358627..2358815 + 189 WP_265322120.1 DUF29 domain-containing protein -
QEN32_RS11245 (2359093) 2359093..2359410 - 318 WP_109187489.1 DUF1493 family protein -
QEN32_RS11250 (2360101) 2360101..2360490 + 390 WP_001044696.1 hypothetical protein -
QEN32_RS11255 (2360493) 2360493..2360846 + 354 WP_000418733.1 hypothetical protein -
QEN32_RS11260 (2361259) 2361259..2361507 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QEN32_RS11265 (2361497) 2361497..2361781 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEN32_RS11270 (2361952) 2361952..2362341 + 390 WP_000194089.1 RidA family protein -
QEN32_RS11275 (2362399) 2362399..2363472 - 1074 WP_000954681.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
QEN32_RS11280 (2363665) 2363665..2364153 - 489 WP_265322121.1 MarR family winged helix-turn-helix transcriptional regulator -
QEN32_RS11285 (2364198) 2364198..2365706 + 1509 WP_000199413.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2354445..2368563 14118
- inside Genomic island - - 2360493..2368563 8070


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T278905 WP_000221345.1 NZ_CP123282:2361497-2361781 [Salmonella sp. SA14318]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT278905 WP_000885424.1 NZ_CP123282:2361259-2361507 [Salmonella sp. SA14318]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References