278900

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1023364..1024178 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag QEN32_RS04870 Protein ID WP_000971655.1
Coordinates 1023364..1023891 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QEN32_RS04875 Protein ID WP_000855694.1
Coordinates 1023888..1024178 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS04845 (1019566) 1019566..1019987 + 422 Protein_948 cytoplasmic protein -
QEN32_RS04850 (1020550) 1020550..1021218 + 669 WP_000445914.1 hypothetical protein -
QEN32_RS04855 (1021245) 1021245..1021739 + 495 WP_000424944.1 hypothetical protein -
QEN32_RS04860 (1021984) 1021984..1022640 - 657 WP_076741749.1 protein-serine/threonine phosphatase -
QEN32_RS04865 (1022867) 1022867..1023291 + 425 Protein_952 transposase -
QEN32_RS04870 (1023364) 1023364..1023891 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
QEN32_RS04875 (1023888) 1023888..1024178 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QEN32_RS04880 (1024772) 1024772..1025098 + 327 WP_242105757.1 hypothetical protein -
QEN32_RS04885 (1025371) 1025371..1025718 - 348 WP_242105758.1 DUF1493 family protein -
QEN32_RS04890 (1025703) 1025703..1026152 - 450 WP_000381619.1 hypothetical protein -
QEN32_RS04895 (1026584) 1026584..1027027 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QEN32_RS04900 (1027484) 1027484..1028134 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1023115..1033447 10332
- flank IS/Tn - - 1023115..1023291 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T278900 WP_000971655.1 NZ_CP123282:c1023891-1023364 [Salmonella sp. SA14318]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT278900 WP_000855694.1 NZ_CP123282:c1024178-1023888 [Salmonella sp. SA14318]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References