Detailed information of TA system TA027890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 417355..418472
• Replicon: chromosome
• Accession: NC_017964
• Organism: Advenella kashmirensis WT001

Toxin (Protein)

• Gene name: -
• Uniprot ID: I3U7X4
• Locus tag: TKWG_RS01910
• Protein ID: WP_014749203.1
• Coordinates: 417355..418101 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: I3U7X5
• Locus tag: TKWG_RS01915
• Protein ID: WP_014749204.1
• Coordinates: 418101..418472 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TKWG_RS23885	412644..412817	-	174	WP_202947756.1	hypothetical protein	-
TKWG_RS01895	413285..413851	-	567	WP_041709767.1	hypothetical protein	-
TKWG_RS01900	413882..415498	-	1617	WP_014749201.1	peptide chain release factor 3	-
TKWG_RS01905	415987..417144	-	1158	WP_014749202.1	Na+/H+ antiporter NhaA	-
TKWG_RS01910	417355..418101	-	747	WP_014749203.1	RES family NAD+ phosphorylase	Toxin
TKWG_RS01915	418101..418472	-	372	WP_014749204.1	XRE family transcriptional regulator	Antitoxin
TKWG_RS01920	418825..419472	+	648	WP_050981502.1	LemA family protein	-
TKWG_RS01925	419514..420435	+	922	Protein_401	YgcG family protein	-
TKWG_RS01930	420425..420922	+	498	WP_050981503.1	TPM domain-containing protein	-
TKWG_RS01935	421139..422533	-	1395	WP_014749207.1	GTPase/DUF3482 domain-containing protein	-
TKWG_RS23485	422530..423234	-	705	WP_014749208.1	DUF2868 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-205)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-47)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28262.10 Da
• Isoelectric Point: 5.9475

>T27890 WP_014749203.1 NC_017964:c418101-417355 [Advenella kashmirensis WT001]
MIWQSCNGPDHIRPIDGKLYRLVESQEQIATLGYVDTLDEQALLEQMLDQAKPVSQPDCEPLHYLLKTPFRYPPLKWGSR
FGRVHERSLFYGGKNIGAVLAESAFYRFVFWHSMDGVPIKDRIRSEHTLFSVRYGTEKGIQLQEPPFDQYQADLTDPVNY
RAAQQIGSAMREANVEAFEYCSARDPEHGLCVALFSPVAFRQKKPQETNQWFGEVSADQVSFTQLRSGKVMTYGIGFFLV
DGVLPMPA

Nucleotide

• Length: 747 bp

>T27890 NC_017964:c418101-417355 [Advenella kashmirensis WT001]
ATGATCTGGCAAAGCTGCAACGGCCCCGATCATATCCGGCCTATAGACGGCAAACTGTACCGGCTCGTGGAAAGCCAGGA
GCAGATTGCCACACTGGGCTACGTAGACACGCTGGACGAACAGGCCCTGCTGGAACAAATGCTGGATCAGGCCAAGCCTG
TTTCGCAACCAGATTGCGAGCCTCTGCATTATCTGCTCAAAACGCCGTTCCGCTACCCGCCGCTCAAATGGGGCTCGCGC
TTTGGCCGCGTGCATGAACGCAGCCTGTTCTATGGGGGCAAGAATATCGGTGCAGTGCTGGCCGAAAGCGCTTTCTATCG
TTTTGTTTTCTGGCACTCAATGGATGGTGTGCCGATCAAGGACAGGATCCGCAGCGAACATACGCTTTTTTCGGTGCGCT
ATGGTACAGAAAAAGGAATACAGCTTCAGGAACCGCCATTTGATCAGTATCAGGCCGACCTGACTGATCCGGTCAATTAC
CGGGCTGCCCAGCAAATTGGCAGTGCCATGCGCGAGGCCAACGTTGAAGCCTTCGAATACTGCTCGGCCCGCGATCCTGA
ACACGGCCTGTGTGTTGCCCTGTTTTCTCCTGTGGCATTCAGACAAAAAAAACCACAAGAGACCAATCAGTGGTTTGGGG
AGGTCAGCGCGGACCAGGTATCGTTCACGCAACTGAGGTCTGGCAAAGTCATGACCTACGGCATCGGCTTTTTTCTGGTC
GATGGCGTCCTGCCCATGCCGGCCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13256.58 Da
• Isoelectric Point: 10.8780

>AT27890 WP_014749204.1 NC_017964:c418472-418101 [Advenella kashmirensis WT001]
MTALQQPKPAAEAVLAKAVLRAAEQLGLKQAELAAVLGMHRTAISRLKTTSSLDPDSKQGELALLLLRLARALFALTGGD
QEWIRHFMRTPNKITGGIPATQIETIQGMTTVLQFVDAIRGKV

Nucleotide

• Length: 372 bp

>AT27890 NC_017964:c418472-418101 [Advenella kashmirensis WT001]
ATGACCGCATTGCAACAACCCAAACCCGCAGCCGAAGCCGTTCTGGCCAAGGCTGTGTTGCGCGCTGCCGAACAACTCGG
CCTGAAACAGGCAGAGCTGGCTGCGGTGCTTGGCATGCACCGCACCGCCATCAGCCGCCTTAAAACCACCTCATCGCTGG
ATCCTGACAGCAAACAGGGGGAACTGGCCTTGCTGCTGTTACGTCTGGCCCGCGCCCTTTTCGCCCTTACGGGTGGCGAT
CAGGAATGGATCCGCCACTTCATGCGCACCCCAAACAAAATCACCGGCGGTATCCCTGCAACCCAAATTGAAACCATCCA
GGGTATGACCACGGTACTGCAGTTTGTTGATGCCATCCGCGGCAAAGTGTAA

Structures

Toxin

• AlphaFold DB: I3U7X4

Antitoxin

• AlphaFold DB: I3U7X5