Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 203488..204248 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag QEN32_RS00945 Protein ID WP_000533909.1
Coordinates 203763..204248 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag QEN32_RS00940 Protein ID WP_000965889.1
Coordinates 203488..203775 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS00930 (200604) 200604..201032 + 429 Protein_184 IS3 family transposase -
QEN32_RS00935 (202146) 202146..203012 - 867 WP_031612771.1 hypothetical protein -
QEN32_RS00940 (203488) 203488..203775 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
QEN32_RS00945 (203763) 203763..204248 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
QEN32_RS00950 (204619) 204619..205158 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
QEN32_RS00955 (205331) 205331..205543 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QEN32_RS00960 (205831) 205831..206121 - 291 WP_000455790.1 HTH-type transcriptional regulator -
QEN32_RS00965 (206560) 206560..207270 + 711 WP_000190524.1 DUF3053 domain-containing protein -
QEN32_RS00970 (207320) 207320..208294 - 975 WP_079944123.1 glyoxylate/hydroxypyruvate reductase GhrB -
QEN32_RS00975 (208524) 208524..209186 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T278897 WP_000533909.1 NZ_CP123282:203763-204248 [Salmonella sp. SA14318]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT278897 WP_000965889.1 NZ_CP123282:203488-203775 [Salmonella sp. SA14318]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References