278896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84085..85708 Replicon plasmid unnamed
Accession NZ_CP123281
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag QEN30_RS25290 Protein ID WP_000088046.1
Coordinates 84383..85708 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag QEN30_RS25285 Protein ID WP_024136327.1
Coordinates 84085..84378 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS25255 79957..81198 + 1242 WP_001053338.1 VWA domain-containing protein -
QEN30_RS25260 81289..81420 + 132 WP_000374059.1 hypothetical protein -
QEN30_RS25265 81761..82042 - 282 WP_000077926.1 hypothetical protein -
QEN30_RS25270 82092..82283 - 192 WP_000398480.1 hypothetical protein -
QEN30_RS25275 82375..82716 - 342 WP_001151575.1 hypothetical protein -
QEN30_RS25280 83089..83481 + 393 WP_000341066.1 hypothetical protein -
QEN30_RS25285 84085..84378 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
QEN30_RS25290 84383..85708 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
QEN30_RS25295 85769..85975 + 207 WP_000134171.1 hypothetical protein -
QEN30_RS25300 86077..86487 + 411 WP_000985911.1 hypothetical protein -
QEN30_RS25305 86500..87315 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
QEN30_RS25310 87569..87994 + 426 WP_001043843.1 hypothetical protein -
QEN30_RS25315 88448..88684 + 237 Protein_86 type I restriction-modification system subunit M N-terminal domain-containing protein -
QEN30_RS25320 88739..89038 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / aac(6')-Ib-cr / ARR-3 / dfrA27 / aadA16 / qacE / blaNDM-1 / mph(A) / aac(3)-IId / tet(A) / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / aac(3)-IVa / aph(4)-Ia / sul2 / floR / oqxA - 1..199024 199024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T278896 WP_000088046.1 NZ_CP123281:84383-85708 [Salmonella sp. SA17155]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT278896 WP_024136327.1 NZ_CP123281:84085-84378 [Salmonella sp. SA17155]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References