278895

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4224172..4224986 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag QEN30_RS20945 Protein ID WP_000971655.1
Coordinates 4224172..4224699 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag QEN30_RS20950 Protein ID WP_000855692.1
Coordinates 4224696..4224986 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS20925 (4219472) 4219472..4222039 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
QEN30_RS20930 (4222198) 4222198..4222719 + 522 WP_000858988.1 hypothetical protein -
QEN30_RS20935 (4222891) 4222891..4223547 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
QEN30_RS20940 (4223894) 4223894..4224099 + 206 Protein_4079 IS5/IS1182 family transposase -
QEN30_RS20945 (4224172) 4224172..4224699 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
QEN30_RS20950 (4224696) 4224696..4224986 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
QEN30_RS20955 (4225256) 4225256..4225434 - 179 Protein_4082 IS3 family transposase -
QEN30_RS20960 (4225675) 4225675..4226001 + 327 WP_000393302.1 hypothetical protein -
QEN30_RS20965 (4226274) 4226274..4226621 - 348 WP_001669174.1 DUF1493 family protein -
QEN30_RS20970 (4226606) 4226606..4227055 - 450 WP_000381610.1 membrane protein -
QEN30_RS20975 (4227486) 4227486..4227929 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QEN30_RS20980 (4228386) 4228386..4229036 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 4223923..4234349 10426
- flank IS/Tn - - 4223923..4224099 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T278895 WP_000971655.1 NZ_CP123280:c4224699-4224172 [Salmonella sp. SA17155]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT278895 WP_000855692.1 NZ_CP123280:c4224986-4224696 [Salmonella sp. SA17155]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References