278894

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4077210..4077835 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag QEN30_RS20290 Protein ID WP_000911336.1
Coordinates 4077437..4077835 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag QEN30_RS20285 Protein ID WP_000557549.1
Coordinates 4077210..4077437 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS20255 (4072255) 4072255..4073772 + 1518 WP_000003339.1 lysine--tRNA ligase -
QEN30_RS20260 (4073848) 4073848..4074393 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
QEN30_RS20265 (4074658) 4074658..4075416 + 759 WP_000244329.1 amidase activator ActS -
QEN30_RS20275 (4075701) 4075701..4076507 - 807 WP_010989071.1 DUF1460 domain-containing protein -
QEN30_RS20280 (4076782) 4076782..4077033 - 252 WP_001540858.1 hypothetical protein -
QEN30_RS20285 (4077210) 4077210..4077437 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
QEN30_RS20290 (4077437) 4077437..4077835 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
QEN30_RS20295 (4078641) 4078641..4079177 + 537 WP_001038506.1 STM3031 family outer membrane protein -
QEN30_RS20300 (4079224) 4079224..4079856 + 633 WP_000835265.1 YfdX family protein -
QEN30_RS20305 (4080575) 4080575..4081159 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4075701..4087026 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T278894 WP_000911336.1 NZ_CP123280:4077437-4077835 [Salmonella sp. SA17155]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT278894 WP_000557549.1 NZ_CP123280:4077210-4077437 [Salmonella sp. SA17155]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References