Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3434523..3435283 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag QEN30_RS17150 Protein ID WP_000533909.1
Coordinates 3434798..3435283 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag QEN30_RS17145 Protein ID WP_000965886.1
Coordinates 3434523..3434810 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS17120 (3429818) 3429818..3430120 + 303 WP_000605590.1 YsaB family lipoprotein -
QEN30_RS17125 (3430259) 3430259..3431170 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
QEN30_RS17130 (3431180) 3431180..3433249 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
QEN30_RS17135 (3433431) 3433431..3433706 + 276 Protein_3335 IS3 family transposase -
QEN30_RS17140 (3433878) 3433878..3434345 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
QEN30_RS17145 (3434523) 3434523..3434810 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
QEN30_RS17150 (3434798) 3434798..3435283 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
QEN30_RS17155 (3435655) 3435655..3436194 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
QEN30_RS17160 (3436368) 3436368..3436580 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QEN30_RS17165 (3436869) 3436869..3437159 - 291 WP_000455790.1 HTH-type transcriptional regulator -
QEN30_RS17170 (3437598) 3437598..3438308 + 711 WP_000190524.1 DUF3053 domain-containing protein -
QEN30_RS17175 (3438358) 3438358..3439332 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
QEN30_RS17180 (3439551) 3439551..3440213 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T278890 WP_000533909.1 NZ_CP123280:3434798-3435283 [Salmonella sp. SA17155]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT278890 WP_000965886.1 NZ_CP123280:3434523-3434810 [Salmonella sp. SA17155]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References