Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 356715..357295 Replicon chromosome
Accession NC_017964
Organism Advenella kashmirensis WT001

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag TKWG_RS22175 Protein ID WP_014749153.1
Coordinates 356715..356903 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag TKWG_RS01655 Protein ID WP_041709757.1
Coordinates 356906..357295 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TKWG_RS01630 351830..353333 - 1504 Protein_340 AMP-binding protein -
TKWG_RS01635 353351..354325 - 975 WP_014749150.1 tripartite tricarboxylate transporter substrate binding protein -
TKWG_RS22895 354434..355195 + 762 Protein_342 IclR family transcriptional regulator -
TKWG_RS01645 355318..355830 + 513 WP_014749151.1 hypothetical protein -
TKWG_RS01650 355827..356414 + 588 WP_014749152.1 peroxidase-related enzyme -
TKWG_RS22175 356715..356903 + 189 WP_014749153.1 type II toxin-antitoxin system HicA family toxin Toxin
TKWG_RS01655 356906..357295 + 390 WP_041709757.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TKWG_RS01660 357320..358141 - 822 WP_014749155.1 SAM-dependent methyltransferase -
TKWG_RS01665 358151..359512 - 1362 WP_014749156.1 oxygen-independent coproporphyrinogen III oxidase -
TKWG_RS01670 359549..362272 - 2724 WP_014749157.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7337.64 Da        Isoelectric Point: 11.2836

>T27889 WP_014749153.1 NC_017964:356715-356903 [Advenella kashmirensis WT001]
MKSDEVIKRLKADGWVWVGGKGDHMKFKHPHKIQHVVVPHPRKDIALGTLRNIYRQAGWKWR

Download         Length: 189 bp

>T27889 NC_017964:356715-356903 [Advenella kashmirensis WT001]
ATGAAGAGTGATGAAGTAATTAAACGATTGAAAGCCGACGGTTGGGTTTGGGTTGGAGGTAAAGGCGATCATATGAAATT
TAAGCATCCCCATAAGATTCAACATGTTGTTGTTCCCCATCCTCGTAAAGATATAGCCTTAGGTACGTTGCGCAATATCT
ATCGCCAGGCTGGCTGGAAATGGAGGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14550.36 Da        Isoelectric Point: 4.3293

>AT27889 WP_041709757.1 NC_017964:356906-357295 [Advenella kashmirensis WT001]
MFYPAYIHKDRDSAYSVTFPDFPGCFTAADELADLPRLAQEAVEVYFEGEDVAIAPPSSFEDWCNDERFQDGCWMLVDID
LSRIDTKAVRLNISLPQNLVHRIDARAKALHMSRSAFLANAAEKEMATS

Download         Length: 390 bp

>AT27889 NC_017964:356906-357295 [Advenella kashmirensis WT001]
ATGTTTTATCCTGCATACATTCACAAAGATCGGGATAGCGCCTACAGCGTGACTTTTCCAGACTTTCCCGGCTGTTTTAC
CGCTGCGGACGAACTCGCTGATTTACCCCGACTGGCGCAGGAGGCTGTGGAGGTTTATTTCGAAGGCGAAGACGTGGCGA
TTGCGCCTCCTTCTTCTTTTGAAGATTGGTGTAACGACGAACGGTTTCAGGACGGCTGCTGGATGCTGGTCGATATTGAT
TTATCAAGAATCGATACAAAGGCGGTACGCCTCAATATCAGCCTGCCGCAAAATCTGGTACACCGCATTGACGCAAGAGC
CAAGGCTTTGCATATGTCACGATCGGCCTTTTTGGCCAATGCAGCGGAAAAGGAAATGGCCACGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References