Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2406241..2406817 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag QEN30_RS12285 Protein ID WP_001131963.1
Coordinates 2406530..2406817 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag QEN30_RS12280 Protein ID WP_000063142.1
Coordinates 2406241..2406543 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS12265 (2402751) 2402751..2404901 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
QEN30_RS12270 (2404996) 2404996..2405199 + 204 WP_000460616.1 YbdD/YjiX family protein -
QEN30_RS12275 (2405210) 2405210..2406166 + 957 WP_000187839.1 GTPase -
QEN30_RS12280 (2406241) 2406241..2406543 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
QEN30_RS12285 (2406530) 2406530..2406817 - 288 WP_001131963.1 BrnT family toxin Toxin
QEN30_RS12290 (2407086) 2407086..2408000 - 915 WP_000290512.1 restriction endonuclease -
QEN30_RS12295 (2408198) 2408198..2411707 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T278885 WP_001131963.1 NZ_CP123280:c2406817-2406530 [Salmonella sp. SA17155]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT278885 WP_000063142.1 NZ_CP123280:c2406543-2406241 [Salmonella sp. SA17155]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References