Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1763716..1764336 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QEN30_RS09180 Protein ID WP_001280991.1
Coordinates 1764118..1764336 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QEN30_RS09175 Protein ID WP_000344807.1
Coordinates 1763716..1764090 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS09165 (1758855) 1758855..1760048 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN30_RS09170 (1760071) 1760071..1763220 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QEN30_RS09175 (1763716) 1763716..1764090 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QEN30_RS09180 (1764118) 1764118..1764336 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QEN30_RS09185 (1764515) 1764515..1765066 + 552 WP_001278792.1 maltose O-acetyltransferase -
QEN30_RS09190 (1765183) 1765183..1765653 + 471 WP_000136181.1 YlaC family protein -
QEN30_RS09195 (1765709) 1765709..1765849 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QEN30_RS09200 (1765855) 1765855..1766115 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QEN30_RS09205 (1766340) 1766340..1767890 + 1551 WP_000213139.1 EAL domain-containing protein -
QEN30_RS09215 (1768121) 1768121..1768510 + 390 WP_000961285.1 MGMT family protein -
QEN30_RS09220 (1768543) 1768543..1769112 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T278882 WP_001280991.1 NZ_CP123280:1764118-1764336 [Salmonella sp. SA17155]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT278882 WP_000344807.1 NZ_CP123280:1763716-1764090 [Salmonella sp. SA17155]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References