Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 104886..105511 Replicon plasmid pYZLc23-1_159k
Accession NZ_CP123267
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4686_RS24215 Protein ID WP_000911313.1
Coordinates 105113..105511 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag N4686_RS24210 Protein ID WP_000450520.1
Coordinates 104886..105113 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS24210 (104886) 104886..105113 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4686_RS24215 (105113) 105113..105511 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
N4686_RS24220 (105520) 105520..107673 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
N4686_RS24225 (107926) 107926..108657 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
N4686_RS24230 (108689) 108689..109186 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / rmtB / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / aph(3')-Ia / fosA3 / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..159725 159725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T278870 WP_000911313.1 NZ_CP123267:105113-105511 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT278870 WP_000450520.1 NZ_CP123267:104886-105113 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References