Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 45055..45698 Replicon plasmid pYZLc23-1_159k
Accession NZ_CP123267
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag N4686_RS23875 Protein ID WP_001044768.1
Coordinates 45282..45698 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag N4686_RS23870 Protein ID WP_001261287.1
Coordinates 45055..45285 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS23855 (41166) 41166..42254 + 1089 WP_000952231.1 hypothetical protein -
N4686_RS23860 (42256) 42256..43125 + 870 WP_000253407.1 hypothetical protein -
N4686_RS23865 (43182) 43182..44747 - 1566 WP_000741348.1 AAA family ATPase -
N4686_RS23870 (45055) 45055..45285 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N4686_RS23875 (45282) 45282..45698 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
N4686_RS23880 (45860) 45860..47998 - 2139 WP_000350638.1 AAA family ATPase -
N4686_RS23885 (48352) 48352..48609 + 258 WP_000343085.1 hypothetical protein -
N4686_RS23890 (48609) 48609..49199 + 591 WP_000194575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / rmtB / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / aph(3')-Ia / fosA3 / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..159725 159725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T278865 WP_001044768.1 NZ_CP123267:45282-45698 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT278865 WP_001261287.1 NZ_CP123267:45055-45285 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References