Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4422058..4422555 Replicon chromosome
Accession NZ_CP123266
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N4686_RS21455 Protein ID WP_001173343.1
Coordinates 4422058..4422231 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag N4686_RS21460 Protein ID WP_000398619.1
Coordinates 4422259..4422555 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS21445 (4418728) 4418728..4420185 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
N4686_RS21450 (4420422) 4420422..4421939 + 1518 WP_001295074.1 lysine--tRNA ligase -
N4686_RS21455 (4422058) 4422058..4422231 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N4686_RS21460 (4422259) 4422259..4422555 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N4686_RS21465 (4422782) 4422782..4423054 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
N4686_RS21470 (4423066) 4423066..4423296 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
N4686_RS21475 (4423477) 4423477..4425108 + 1632 WP_001216486.1 sensor histidine kinase -
N4686_RS21480 (4425105) 4425105..4425824 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278863 WP_001173343.1 NZ_CP123266:c4422231-4422058 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278863 WP_000398619.1 NZ_CP123266:c4422555-4422259 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References