278859

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3638141..3638978 Replicon chromosome
Accession NZ_CP123266
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag N4686_RS17750 Protein ID WP_000227784.1
Coordinates 3638436..3638978 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag N4686_RS17745 Protein ID WP_001297137.1
Coordinates 3638141..3638452 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS17720 (3633161) 3633161..3634108 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
N4686_RS17725 (3634130) 3634130..3636121 + 1992 WP_134233412.1 cytochrome o ubiquinol oxidase subunit I -
N4686_RS17730 (3636111) 3636111..3636725 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
N4686_RS17735 (3636725) 3636725..3637054 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
N4686_RS17740 (3637066) 3637066..3637956 + 891 WP_000971336.1 heme o synthase -
N4686_RS17745 (3638141) 3638141..3638452 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
N4686_RS17750 (3638436) 3638436..3638978 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
N4686_RS17755 (3639034) 3639034..3639969 - 936 WP_001297127.1 tetratricopeptide repeat protein -
N4686_RS17760 (3640377) 3640377..3641741 + 1365 WP_023143167.1 MFS transporter -
N4686_RS17765 (3641869) 3641869..3642360 - 492 WP_001138904.1 nucleotide binding protein YajQ -
N4686_RS17770 (3642528) 3642528..3643439 + 912 WP_000705877.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T278859 WP_000227784.1 NZ_CP123266:3638436-3638978 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT278859 WP_001297137.1 NZ_CP123266:3638141-3638452 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References