Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3604052..3604670 Replicon chromosome
Accession NZ_CP123266
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4686_RS17580 Protein ID WP_001291435.1
Coordinates 3604452..3604670 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4686_RS17575 Protein ID WP_000344800.1
Coordinates 3604052..3604426 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS17565 (3599141) 3599141..3600334 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4686_RS17570 (3600357) 3600357..3603506 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N4686_RS17575 (3604052) 3604052..3604426 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4686_RS17580 (3604452) 3604452..3604670 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N4686_RS17585 (3604841) 3604841..3605392 + 552 WP_000102578.1 maltose O-acetyltransferase -
N4686_RS17590 (3605508) 3605508..3605978 + 471 WP_000136192.1 YlaC family protein -
N4686_RS17595 (3606142) 3606142..3607692 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4686_RS17600 (3607734) 3607734..3608087 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N4686_RS17610 (3608466) 3608466..3608777 + 312 WP_000409911.1 MGMT family protein -
N4686_RS17615 (3608808) 3608808..3609380 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278858 WP_001291435.1 NZ_CP123266:3604452-3604670 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278858 WP_000344800.1 NZ_CP123266:3604052-3604426 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References