Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1336131..1336756 Replicon chromosome
Accession NZ_CP123266
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag N4686_RS06520 Protein ID WP_000911329.1
Coordinates 1336358..1336756 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N4686_RS06515 Protein ID WP_000450524.1
Coordinates 1336131..1336358 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS06490 (1331933) 1331933..1332403 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N4686_RS06495 (1332403) 1332403..1332975 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N4686_RS06500 (1333121) 1333121..1333999 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
N4686_RS06505 (1334016) 1334016..1335050 + 1035 WP_023142816.1 outer membrane protein assembly factor BamC -
N4686_RS06510 (1335263) 1335263..1335976 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N4686_RS06515 (1336131) 1336131..1336358 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4686_RS06520 (1336358) 1336358..1336756 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
N4686_RS06525 (1336903) 1336903..1337766 + 864 WP_001267498.1 neutral zinc metallopeptidase -
N4686_RS06530 (1337781) 1337781..1339796 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
N4686_RS06535 (1339870) 1339870..1340568 + 699 WP_000679823.1 esterase -
N4686_RS06540 (1340678) 1340678..1340878 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T278850 WP_000911329.1 NZ_CP123266:1336358-1336756 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278850 WP_000450524.1 NZ_CP123266:1336131-1336358 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References