Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 12922..13565 Replicon plasmid pYZLc4-1_94k
Accession NZ_CP123263
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name vagD Uniprot ID A0A1L4J633
Locus tag N4697_RS25155 Protein ID WP_047612429.1
Coordinates 12922..13338 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A627FA37
Locus tag N4697_RS25160 Protein ID WP_001604445.1
Coordinates 13335..13565 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS25140 (N4697_025145) 8600..9595 - 996 WP_000246636.1 hypothetical protein -
N4697_RS25145 (N4697_025150) 10024..11595 + 1572 WP_047613524.1 ATP-binding protein -
N4697_RS25150 (N4697_025155) 11802..12782 - 981 WP_089576189.1 hypothetical protein -
N4697_RS25155 (N4697_025160) 12922..13338 - 417 WP_047612429.1 type II toxin-antitoxin system VapC family toxin Toxin
N4697_RS25160 (N4697_025165) 13335..13565 - 231 WP_001604445.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N4697_RS25165 (N4697_025170) 13522..13712 + 191 Protein_15 hypothetical protein -
N4697_RS25170 (N4697_025175) 13918..14919 + 1002 WP_000785695.1 DUF4238 domain-containing protein -
N4697_RS25175 (N4697_025180) 15093..15437 - 345 WP_000792769.1 hypothetical protein -
N4697_RS25180 (N4697_025185) 15935..16189 - 255 WP_000678528.1 hypothetical protein -
N4697_RS25185 (N4697_025190) 16239..17165 - 927 WP_001290414.1 hypothetical protein -
N4697_RS25190 (N4697_025195) 17698..18012 + 315 WP_001302628.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..94872 94872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15064.41 Da        Isoelectric Point: 6.7125

>T278843 WP_047612429.1 NZ_CP123263:c13338-12922 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8736.84 Da        Isoelectric Point: 4.4692

>AT278843 WP_001604445.1 NZ_CP123263:c13565-13335 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4J633

Antitoxin

Source ID Structure
AlphaFold DB A0A627FA37

References