Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4295764..4296359 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag N4697_RS20770 Protein ID WP_000239581.1
Coordinates 4295764..4296114 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag N4697_RS20775 Protein ID WP_001223213.1
Coordinates 4296108..4296359 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS20750 (4291218) 4291218..4292240 - 1023 WP_063625321.1 ABC transporter permease -
N4697_RS20755 (4292254) 4292254..4293756 - 1503 WP_063625322.1 sugar ABC transporter ATP-binding protein -
N4697_RS20760 (4293889) 4293889..4294845 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N4697_RS20765 (4295155) 4295155..4295685 + 531 WP_000055075.1 inorganic diphosphatase -
N4697_RS20770 (4295764) 4295764..4296114 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
N4697_RS20775 (4296108) 4296108..4296359 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N4697_RS20780 (4296571) 4296571..4296912 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N4697_RS20785 (4296915) 4296915..4300694 - 3780 WP_063625323.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T278835 WP_000239581.1 NZ_CP123260:c4296114-4295764 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT278835 WP_001223213.1 NZ_CP123260:c4296359-4296108 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References