Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4284420..4284942 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N4697_RS20710 Protein ID WP_104773392.1
Coordinates 4284420..4284710 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag N4697_RS20715 Protein ID WP_000212715.1
Coordinates 4284700..4284942 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS20695 (4279588) 4279588..4281243 + 1656 WP_063625319.1 alpha,alpha-phosphotrehalase -
N4697_RS20700 (4281637) 4281637..4283775 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
N4697_RS20705 (4283955) 4283955..4284419 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4697_RS20710 (4284420) 4284420..4284710 - 291 WP_104773392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4697_RS20715 (4284700) 4284700..4284942 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4697_RS20720 (4285134) 4285134..4285520 - 387 WP_001232253.1 cytochrome b562 -
N4697_RS20725 (4285576) 4285576..4286928 - 1353 WP_063625320.1 metalloprotease PmbA -
N4697_RS20730 (4287022) 4287022..4287573 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
N4697_RS20735 (4287656) 4287656..4289029 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T278834 WP_104773392.1 NZ_CP123260:c4284710-4284420 [Escherichia coli]
MNYELAFDPRALKEWQKLGVAVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVITIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT278834 WP_000212715.1 NZ_CP123260:c4284942-4284700 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References