278832

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3648548..3649385 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag N4697_RS17855 Protein ID WP_000227784.1
Coordinates 3648843..3649385 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag N4697_RS17850 Protein ID WP_001297137.1
Coordinates 3648548..3648859 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS17825 (3643568) 3643568..3644515 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
N4697_RS17830 (3644537) 3644537..3646528 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
N4697_RS17835 (3646518) 3646518..3647132 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
N4697_RS17840 (3647132) 3647132..3647461 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
N4697_RS17845 (3647473) 3647473..3648363 + 891 WP_000971336.1 heme o synthase -
N4697_RS17850 (3648548) 3648548..3648859 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
N4697_RS17855 (3648843) 3648843..3649385 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
N4697_RS17860 (3649441) 3649441..3650376 - 936 WP_001297127.1 tetratricopeptide repeat protein -
N4697_RS17865 (3650784) 3650784..3652148 + 1365 WP_001000974.1 MFS transporter -
N4697_RS17870 (3652276) 3652276..3652767 - 492 WP_001138904.1 nucleotide binding protein YajQ -
N4697_RS17875 (3652935) 3652935..3653846 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T278832 WP_000227784.1 NZ_CP123260:3648843-3649385 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT278832 WP_001297137.1 NZ_CP123260:3648548-3648859 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References