Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3614468..3615086 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4697_RS17685 Protein ID WP_001291435.1
Coordinates 3614868..3615086 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4697_RS17680 Protein ID WP_000344800.1
Coordinates 3614468..3614842 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS17670 (3609557) 3609557..3610750 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4697_RS17675 (3610773) 3610773..3613922 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N4697_RS17680 (3614468) 3614468..3614842 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4697_RS17685 (3614868) 3614868..3615086 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N4697_RS17690 (3615258) 3615258..3615809 + 552 WP_262934964.1 maltose O-acetyltransferase -
N4697_RS17695 (3615925) 3615925..3616395 + 471 WP_000136192.1 YlaC family protein -
N4697_RS17700 (3616559) 3616559..3618109 + 1551 WP_063625273.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4697_RS17705 (3618151) 3618151..3618504 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N4697_RS17715 (3618883) 3618883..3619194 + 312 WP_000409911.1 MGMT family protein -
N4697_RS17720 (3619225) 3619225..3619797 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278831 WP_001291435.1 NZ_CP123260:3614868-3615086 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278831 WP_000344800.1 NZ_CP123260:3614468-3614842 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References