Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2498040..2498678 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N4697_RS12165 Protein ID WP_000813794.1
Coordinates 2498502..2498678 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4697_RS12160 Protein ID WP_001270286.1
Coordinates 2498040..2498456 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS12140 (2493192) 2493192..2494133 - 942 WP_001251315.1 ABC transporter permease -
N4697_RS12145 (2494134) 2494134..2495147 - 1014 WP_063625587.1 ABC transporter ATP-binding protein -
N4697_RS12150 (2495165) 2495165..2496310 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
N4697_RS12155 (2496555) 2496555..2497961 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
N4697_RS12160 (2498040) 2498040..2498456 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N4697_RS12165 (2498502) 2498502..2498678 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N4697_RS12170 (2498900) 2498900..2499130 + 231 WP_000494244.1 YncJ family protein -
N4697_RS12175 (2499222) 2499222..2501183 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N4697_RS12180 (2501256) 2501256..2501792 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N4697_RS12185 (2501884) 2501884..2503059 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2503099..2504247 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278830 WP_000813794.1 NZ_CP123260:c2498678-2498502 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278830 WP_001270286.1 NZ_CP123260:c2498456-2498040 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References