Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1354273..1354898 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4697_RS06620 Protein ID WP_000911330.1
Coordinates 1354500..1354898 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N4697_RS06615 Protein ID WP_000450524.1
Coordinates 1354273..1354500 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS06590 (1350076) 1350076..1350546 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N4697_RS06595 (1350546) 1350546..1351118 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N4697_RS06600 (1351264) 1351264..1352142 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N4697_RS06605 (1352159) 1352159..1353193 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N4697_RS06610 (1353406) 1353406..1354119 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N4697_RS06615 (1354273) 1354273..1354500 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4697_RS06620 (1354500) 1354500..1354898 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N4697_RS06625 (1355045) 1355045..1355908 + 864 WP_001267507.1 neutral zinc metallopeptidase -
N4697_RS06630 (1355923) 1355923..1357938 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
N4697_RS06635 (1358012) 1358012..1358710 + 699 WP_000679812.1 esterase -
N4697_RS06640 (1358820) 1358820..1359020 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278824 WP_000911330.1 NZ_CP123260:1354500-1354898 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278824 WP_000450524.1 NZ_CP123260:1354273-1354500 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References