Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 915491..916145 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag N4697_RS04485 Protein ID WP_000244772.1
Coordinates 915738..916145 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N4697_RS04480 Protein ID WP_000354046.1
Coordinates 915491..915757 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS04455 (910779) 910779..911522 + 744 WP_000951964.1 SDR family oxidoreductase -
N4697_RS04460 (911579) 911579..913012 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
N4697_RS04465 (913057) 913057..913368 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
N4697_RS04470 (913532) 913532..914191 + 660 WP_000250274.1 hemolysin III family protein -
N4697_RS04475 (914268) 914268..915248 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
N4697_RS04480 (915491) 915491..915757 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N4697_RS04485 (915738) 915738..916145 + 408 WP_000244772.1 protein YgfX Toxin
N4697_RS04490 (916185) 916185..916706 - 522 WP_063625410.1 flavodoxin FldB -
N4697_RS04495 (916818) 916818..917714 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N4697_RS04500 (917739) 917739..918449 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4697_RS04505 (918455) 918455..920188 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T278821 WP_000244772.1 NZ_CP123260:915738-916145 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278821 WP_000354046.1 NZ_CP123260:915491-915757 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References