Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 331602..332402 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag N4697_RS01540 Protein ID WP_000342451.1
Coordinates 331875..332402 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag N4697_RS01535 Protein ID WP_001277108.1
Coordinates 331602..331868 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS01515 (327260) 327260..327928 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
N4697_RS01520 (327921) 327921..328979 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
N4697_RS01525 (329223) 329223..330077 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
N4697_RS01530 (330349) 330349..331452 + 1104 WP_078167906.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
N4697_RS01535 (331602) 331602..331868 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
N4697_RS01540 (331875) 331875..332402 + 528 WP_000342451.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
N4697_RS01545 (332399) 332399..332782 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
N4697_RS01550 (333206) 333206..334315 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
N4697_RS01555 (334363) 334363..335289 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
N4697_RS01560 (335286) 335286..336563 + 1278 WP_000803798.1 branched chain amino acid ABC transporter permease LivM -
N4697_RS01565 (336560) 336560..337327 + 768 WP_000082110.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19749.73 Da        Isoelectric Point: 7.3232

>T278819 WP_000342451.1 NZ_CP123260:331875-332402 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAELPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT278819 WP_001277108.1 NZ_CP123260:331602-331868 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References