Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4375041..4375538 Replicon chromosome
Accession NZ_CP123255
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N4680_RS21235 Protein ID WP_001173343.1
Coordinates 4375041..4375214 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag N4680_RS21240 Protein ID WP_000398619.1
Coordinates 4375242..4375538 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS21225 (4371711) 4371711..4373168 + 1458 WP_186185490.1 dipeptide/tripeptide permease DtpC -
N4680_RS21230 (4373405) 4373405..4374922 + 1518 WP_001295074.1 lysine--tRNA ligase -
N4680_RS21235 (4375041) 4375041..4375214 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N4680_RS21240 (4375242) 4375242..4375538 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N4680_RS21245 (4375765) 4375765..4376037 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
N4680_RS21250 (4376049) 4376049..4376279 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
N4680_RS21255 (4376460) 4376460..4378091 + 1632 WP_001216477.1 sensor histidine kinase -
N4680_RS21260 (4378088) 4378088..4378807 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278813 WP_001173343.1 NZ_CP123255:c4375214-4375041 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278813 WP_000398619.1 NZ_CP123255:c4375538-4375242 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References