Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2500907..2501545 Replicon chromosome
Accession NZ_CP123255
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag N4680_RS12080 Protein ID WP_001447010.1
Coordinates 2501369..2501545 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4680_RS12075 Protein ID WP_001270286.1
Coordinates 2500907..2501323 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS12055 (2496059) 2496059..2497000 - 942 WP_001251304.1 ABC transporter permease -
N4680_RS12060 (2497001) 2497001..2498014 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N4680_RS12065 (2498032) 2498032..2499177 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N4680_RS12070 (2499422) 2499422..2500828 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N4680_RS12075 (2500907) 2500907..2501323 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N4680_RS12080 (2501369) 2501369..2501545 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N4680_RS12085 (2501767) 2501767..2501997 + 231 WP_000494244.1 YncJ family protein -
N4680_RS12090 (2502089) 2502089..2504050 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N4680_RS12095 (2504123) 2504123..2504659 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N4680_RS12100 (2504751) 2504751..2505926 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T278807 WP_001447010.1 NZ_CP123255:c2501545-2501369 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278807 WP_001270286.1 NZ_CP123255:c2501323-2500907 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References