Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 886872..887526 Replicon chromosome
Accession NZ_CP123255
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N4680_RS04400 Protein ID WP_000244781.1
Coordinates 887119..887526 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N4680_RS04395 Protein ID WP_000354046.1
Coordinates 886872..887138 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS04375 (882960) 882960..884393 - 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -
N4680_RS04380 (884438) 884438..884749 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
N4680_RS04385 (884913) 884913..885572 + 660 WP_000250269.1 hemolysin III family protein -
N4680_RS04390 (885649) 885649..886629 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
N4680_RS04395 (886872) 886872..887138 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N4680_RS04400 (887119) 887119..887526 + 408 WP_000244781.1 protein YgfX Toxin
N4680_RS04405 (887566) 887566..888087 - 522 WP_001521233.1 flavodoxin FldB -
N4680_RS04410 (888199) 888199..889095 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N4680_RS04415 (889120) 889120..889830 + 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4680_RS04420 (889836) 889836..891569 + 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T278798 WP_000244781.1 NZ_CP123255:887119-887526 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278798 WP_000354046.1 NZ_CP123255:886872-887138 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References