Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4532805..4534381 Replicon chromosome
Accession NZ_CP123251
Organism Providencia rettgeri strain YZLc5-3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N4838_RS20775 Protein ID WP_094961980.1
Coordinates 4532805..4534124 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N4838_RS20780 Protein ID WP_036959176.1
Coordinates 4534124..4534381 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4838_RS20765 (N4838_020835) 4528742..4531789 - 3048 WP_282550878.1 formate dehydrogenase-N subunit alpha -
N4838_RS20770 (N4838_020840) 4531964..4532794 + 831 WP_036959175.1 formate dehydrogenase accessory sulfurtransferase FdhD -
N4838_RS20775 (N4838_020845) 4532805..4534124 - 1320 WP_094961980.1 type II toxin-antitoxin system HipA family toxin Toxin
N4838_RS20780 (N4838_020850) 4534124..4534381 - 258 WP_036959176.1 helix-turn-helix domain-containing protein Antitoxin
N4838_RS20785 (N4838_020855) 4534704..4536068 - 1365 WP_004906223.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
N4838_RS20790 (N4838_020860) 4536169..4537818 - 1650 WP_004906225.1 membrane protein insertase YidC -
N4838_RS20795 (N4838_020865) 4537821..4538081 - 261 WP_036959180.1 membrane protein insertion efficiency factor YidD -
N4838_RS20800 (N4838_020870) 4538045..4538404 - 360 WP_004906229.1 ribonuclease P protein component -
N4838_RS20805 (N4838_020875) 4538426..4538569 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50006.01 Da        Isoelectric Point: 6.6933

>T278792 WP_094961980.1 NZ_CP123251:c4534124-4532805 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPRSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVIKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.85 Da        Isoelectric Point: 9.6898

>AT278792 WP_036959176.1 NZ_CP123251:c4534381-4534124 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References