Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4442791..4443374 Replicon chromosome
Accession NZ_CP123251
Organism Providencia rettgeri strain YZLc5-3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag N4838_RS20380 Protein ID WP_096863599.1
Coordinates 4443072..4443374 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N4838_RS20375 Protein ID WP_004265229.1
Coordinates 4442791..4443075 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4838_RS20350 (N4838_020415) 4437951..4438928 - 978 WP_004265237.1 6-phosphofructokinase -
N4838_RS20355 (N4838_020420) 4439335..4440279 - 945 WP_102140623.1 phosphatidate cytidylyltransferase -
N4838_RS20360 (N4838_020425) 4440276..4440917 - 642 WP_140172874.1 lysophospholipid acyltransferase family protein -
N4838_RS20365 (N4838_020430) 4441155..4441907 - 753 WP_004907010.1 M48 family metallopeptidase -
N4838_RS20370 (N4838_020435) 4442127..4442708 - 582 WP_094961882.1 HutD family protein -
N4838_RS20375 (N4838_020440) 4442791..4443075 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
N4838_RS20380 (N4838_020445) 4443072..4443374 - 303 WP_096863599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4838_RS20385 (N4838_020450) 4443619..4444188 - 570 WP_215954265.1 Spy/CpxP family protein refolding chaperone -
N4838_RS20390 (N4838_020455) 4444339..4445037 + 699 WP_004265224.1 envelope stress response regulator transcription factor CpxR -
N4838_RS20395 (N4838_020460) 4445034..4446404 + 1371 WP_215954266.1 envelope stress sensor histidine kinase CpxA -
N4838_RS20400 (N4838_020465) 4446878..4448314 + 1437 WP_239354294.1 capsule assembly Wzi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11433.37 Da        Isoelectric Point: 10.0723

>T278791 WP_096863599.1 NZ_CP123251:c4443374-4443072 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT278791 WP_004265229.1 NZ_CP123251:c4443075-4442791 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References