Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2949260..2949795 Replicon chromosome
Accession NZ_CP123251
Organism Providencia rettgeri strain YZLc5-3

Toxin (Protein)


Gene name ccdB Uniprot ID D4BV22
Locus tag N4838_RS13295 Protein ID WP_004255694.1
Coordinates 2949487..2949795 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D4BV21
Locus tag N4838_RS13290 Protein ID WP_004255691.1
Coordinates 2949260..2949487 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4838_RS13270 (N4838_013305) 2944542..2944982 + 441 WP_110591516.1 flagellar export chaperone FlgN -
N4838_RS13275 (N4838_013310) 2945169..2945600 + 432 WP_140170720.1 hypothetical protein -
N4838_RS13280 (N4838_013315) 2945753..2947852 - 2100 WP_004255687.1 flagellar biosynthesis protein FlhA -
N4838_RS13285 (N4838_013320) 2947845..2948996 - 1152 WP_140170721.1 flagellar biosynthesis protein FlhB -
N4838_RS13290 (N4838_013325) 2949260..2949487 + 228 WP_004255691.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N4838_RS13295 (N4838_013330) 2949487..2949795 + 309 WP_004255694.1 CcdB family protein Toxin
N4838_RS13300 (N4838_013335) 2949811..2950368 + 558 WP_004255696.1 hypothetical protein -
N4838_RS13305 (N4838_013340) 2950411..2950617 - 207 WP_272661075.1 helix-turn-helix transcriptional regulator -
N4838_RS13310 (N4838_013345) 2950815..2951453 - 639 WP_094961165.1 protein phosphatase CheZ -
N4838_RS13315 (N4838_013350) 2951478..2951870 - 393 WP_004255705.1 chemotaxis response regulator CheY -
N4838_RS13320 (N4838_013355) 2951912..2952979 - 1068 WP_262960468.1 chemotaxis response regulator protein-glutamate methylesterase -
N4838_RS13325 (N4838_013360) 2952979..2953815 - 837 WP_004255713.1 chemotaxis protein-glutamate O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11763.84 Da        Isoelectric Point: 7.2408

>T278788 WP_004255694.1 NZ_CP123251:2949487-2949795 [Providencia rettgeri]
MQYCLYQNREDTVKYPYLLDIQSNIIDILNTRLVIPLFDSRLVKKPLPVRLNPQLSINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8688.92 Da        Isoelectric Point: 8.9375

>AT278788 WP_004255691.1 NZ_CP123251:2949260-2949487 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4BV22

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q922

References