278787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2425193..2426109 Replicon chromosome
Accession NZ_CP123251
Organism Providencia rettgeri strain YZLc5-3

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N4838_RS10750 Protein ID WP_164455662.1
Coordinates 2425651..2426109 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID D4BTW8
Locus tag N4838_RS10745 Protein ID WP_004254502.1
Coordinates 2425193..2425654 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4838_RS10715 (N4838_010740) 2420859..2421473 + 615 WP_262960690.1 LysE family translocator -
N4838_RS10720 (N4838_010745) 2421497..2421970 - 474 WP_036957747.1 NUDIX domain-containing protein -
N4838_RS10725 (N4838_010750) 2422322..2422963 - 642 WP_004254492.1 leucine efflux protein LeuE -
N4838_RS10730 (N4838_010755) 2423476..2424138 + 663 WP_282553829.1 AzlC family ABC transporter permease -
N4838_RS10735 (N4838_010760) 2424135..2424449 + 315 WP_004254498.1 AzlD domain-containing protein -
N4838_RS10740 (N4838_010765) 2424637..2425104 + 468 WP_036957750.1 DUF1456 family protein -
N4838_RS10745 (N4838_010770) 2425193..2425654 + 462 WP_004254502.1 DUF2384 domain-containing protein Antitoxin
N4838_RS10750 (N4838_010775) 2425651..2426109 + 459 WP_164455662.1 RES domain-containing protein Toxin
N4838_RS10755 (N4838_010780) 2426110..2427000 - 891 WP_096863730.1 LysR family transcriptional regulator -
N4838_RS10760 (N4838_010785) 2427046..2428005 - 960 WP_187710336.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
N4838_RS10765 (N4838_010790) 2428111..2428533 - 423 WP_262960689.1 helix-turn-helix domain-containing protein -
N4838_RS10770 (N4838_010795) 2428564..2429091 - 528 WP_036957752.1 GNAT family N-acetyltransferase -
N4838_RS10775 (N4838_010800) 2429108..2430574 - 1467 WP_036957754.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-145)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17158.71 Da        Isoelectric Point: 6.4824

>T278787 WP_164455662.1 NZ_CP123251:2425651-2426109 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDRLLNQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Download         Length: 459 bp

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17090.56 Da        Isoelectric Point: 9.9140

>AT278787 WP_004254502.1 NZ_CP123251:2425193-2425654 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q7V6

References